Other Research

The following abstracts and summaries of research include papers written on the use of straight seawater as well as experiments performed using Quinton Plasma.  Whilst positive results were obtained from using straight seawater largely researched in Japan, the volumes consumed were frequently much higher than normally used when supporting the body with Original Quinton products thus indicating the additional efficacy of using Quinton products over simple seawater.

Reduction of Allergic Skin Responses and Serum Allergen-Specific IgE and IgE-Inducing Cytokines by Drinking Deep-Sea Water in Patients with Allergic Rhinitis  Hajime Kimata, Hideyuki Tai, Hiroshi Nakajima. Otorhinolaryngol Nova 2001;11:302–303

Abstract: Deep-sea water intake reduces allergic skin responses and serum levels of total IgE, Japanese cedar pollen-specific IgE, interleukin (IL)-4, IL-6, IL-13, and IL-18 in patients with allergic rhinitis, while distilled water intake fails to do so.

Paper in .pdf format

Hypersaline nasal irrigation in children with symptomatic seasonal allergic rhinitis: A randomised study. Garavello W, Romagnoli M, Sordo L, Gaini R M, Di Berardino C. Pediatr Allergy Immunol 2003:14:140–143.2003 Blackwell Munksgaard

Abstract: Recent evidence suggests that nasal irrigation with hypertonic saline may be useful as anadjunctive treatment modality in the management of many sino-nasal diseases.However, no previous studies have investigated the efficacy of this regimen in the prevention of seasonal allergic rhinitis-related symptoms in the pediatric patient.  Twenty children with seasonal allergic rhinitis to Parietaria were enrolled in the study.  Ten children were randomized to receive three-times daily nasal irrigation with hypertonic saline for the entire pollen season, which had lasted 6 weeks.  Ten patients were allocated to receive no nasal irrigation and were used as controls.  A mean daily rhinitis score based on the presence of nasal itching, rhinorrea, nasal obstruction and sneezing was calculated for each week of the pollen season.More over,patients were allowed to use oral antihistamines when required and the mean number of drug assumption per week was also calculated. In patients allocated to nasal irrigation, the mean daily rhinitis score was reduced during 5 weeks of the study period.  This reduction was statistically significantly different in the 3th, 4th and 5th week of therapy.  Moreover, a decreased consumption of oral antihistamines was observed in these patients.This effect became evident after the second week of treatment and resulted in statistically significant differences during the 3th, 4th and 6th week. This study supports the use of nasal irrigation with hypertonic saline in the pediatric patient with seasonal allergic rhinitis during the pollen season.

Paper in .pdf format

Difference between Deep Seawater and Surface Seawater in the Preventive Effect of Atherosclerosis Mitsuhiko MIYAMURA, Saburo YOSHIOKA, Atsuhide HAMADA, Daisuke TAKUMA,  Junko YOKOTA, Masahiko KUSUNOSE, Shojiro KYOTANI, Hirohisa KAWAKITA, Kazuhiro ODANI, Yasuyuki TSUTSUI, Yutaka NISHIOKA. Biol. Pharm. Bull.27(11) 1784-1787 (2004)

Using surface and deep seawater collected in the sea area of Muroto Cape (Kochi, Japan), desalinated drinking samples of about 1200 hardness were prepared and examined for the effects on the prevention of atherosclerosis in dietary induced hyperlipidemia rabbits. The plasma LDL cholesterol level was lower in the deep seawater group than in the surface seawater group. GPx activity was significantly higher in the deep seawater group than in the control group, while there was no difference between the surface seawater and control groups. The level of LPO was also significantly lower in the deep seawater group than in the control group. The Sudan IV lipid stained area ratio on the inner surface of the aorta was significantly lower in the deep seawater groups than in the control group, while there was no difference between the surface seawater and control groups. The oil red O stained cross section of the aorta in the control and surface seawater administration group foam cells had accumulated to form thick layers, while in the deep seawater administration group, the degree of their accumulation was very low. These results suggested that the deep seawater was useful for the prevention of hyperlipidemia and arteriosclerosis compared to the surface seawater, and it was found that reduction of the LDL cholesterol level and enhancement of GPx activity were involved in its effects.

Paper in .pdf format

Improvement of Skin Symptoms and Mineral Imbalance by Drinking Deep Sea Water in Patients with Atopic Eczema/Dermatitis Syndrome (AEDS)  Hajime Kimata, Hideyuki Tai, Koji Nakagawa, Yoshindo Yokoyama, Hiroshi Nakajima, Yoshinari Ikegami. ACTA MEDICA 2002, Vol.45 No.2

Summary: Deep sea water intake improves skin symptoms and mineral imbalance and decreases serum IgE levels and IgE inducing cytokines, IL-4, IL-13 and IL-18 in patients with atopic eczema/dermatitis syndrome (AEDS), while distilled water intake fails to do so.

Paper in .pdf format

Pharmacological Activity of Deep-Sea Water: Examination of Hyperlipemia Prevention and Medical Treatment Effect. Saburo YOSHIOKA, Atsuhide HAMADA, Tailin CUI, Junko YOKOTA, Sayaka YAMAMOTO, Masahiko KUSUNOSE, Mitsuhiko MIYAMURA, Shojiro KYOTANI, Ryou KANEDA, Yasuyuki TSUTSUI. Biol. Pharm. Bull. (2003) 26(11) 1552—1559

Abstract: When normal rabbits were administered various samples of deep-sea water, their biochemical values changed within normal limits, and no differences from distilled water administration (control) group levels were observed. Furthermore, no histopathological changes were observed in internal organs on the 28th day after administration. The serum total cholesterol (T-Cho) and low density lipoprotein cholesterol (LDL-Cho) levels of normal rabbits fed with a 1% cholesterol-containing diet simultaneously administered deep-sea water (desalinated water, hardness 28, 300, and 1200) increased with time up to about 1500 mg/dl. However, the degrees of increase were smaller than those of the control group, which received distilled water. Furthermore, when prepared hyperlipemia rabbits were administered deep-sea water (desalinated water, hardness 28, 300, and 1200), there were no significant changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), high density lipoprotein cholesterol (HDL-Cho), or triglyceride (TG) levels. On the other hand, T-Cho and LDL-Cho levels were reduced when the rabbits were changed to normal food, and the degree of reduction was more than that of the control group. In the liver and main artery bow, as the hardness of the deep-sea water increased, the accumulation of lipid and permeation of macrophages was reduced. This result was well in agreement with the results of the T-Cho and LDL-Cho levels. From these results, it is clear that deep-sea water controls the increase of serum lipid values (T-Cho and LDL-Cho) of cholesterol-fed rabbits, and promotes the reduction of serum lipid hyperlipemia rabbits. The minerals in deep-sea water greatly influence this effect.

Paper in .pdf format

Breathe easier with saltwater. Saline solution helps lessen symptoms of cystic fibrosis. Article appeared in the News & Observer on 19.01.2006

Link here